InnateDB Protein
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IDBP-197595.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hs2st1
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Protein Name
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heparan sulfate 2-O-sulfotransferase 1
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Synonyms
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AW214369; Hs2st; mKIAA0448;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000043066
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InnateDB Gene
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IDBG-197593 (Hs2st1)
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Protein Structure
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Function |
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O- sulfation of both L-iduronyl and D-glucuronyl residues. {ECO:0000269PubMed:11331020, ECO:0000269PubMed:11457822, ECO:0000269PubMed:9637690}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:11687650}; Single-pass type II membrane protein {ECO:0000269PubMed:11687650}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed at higher level in lung and brain. Weakly expressed in spleen. {ECO:0000269PubMed:11331020, ECO:0000269PubMed:9637690}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004394
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heparan sulfate 2-O-sulfotransferase activity
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GO:0008146
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sulfotransferase activity
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Biological Process |
GO:0015014
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heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
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GO:0030202
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heparin metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0060676
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ureteric bud formation
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Cellular Component |
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PDB ID |
MGI:1346049
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InterPro |
IPR005331
Sulfotransferase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF03567
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R3H7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23908
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UniGene |
Mm.465945
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RefSeq |
NP_035958
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MGI ID |
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MGI Symbol |
Hs2st1
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OMIM |
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CCDS |
CCDS17883
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HPRD |
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IMGT |
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EMBL |
AF060178
AF169243
AK088698
AK165112
BC025443
BC059008
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GenPept |
AAC40135
AAF59900
AAH25443
AAH59008
BAC40511
BAE38041
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