InnateDB Protein
|
IDBP-197704.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Memo1
|
Protein Name
|
mediator of cell motility 1
|
Synonyms
|
0610016J10Rik; D930048L02Rik;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000077553
|
InnateDB Gene
|
IDBG-197700 (Memo1)
|
Protein Structure
|
|
Function |
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). {ECO:0000250}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0032886
|
regulation of microtubule-based process
|
|
Cellular Component |
|
PDB ID |
MGI:1924140
|
InterPro |
IPR002737
MEMO1 family
|
PFAM |
PF01875
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q91VH6
|
PhosphoSite |
PhosphoSite-Q91VH6
|
TrEMBL |
Q3TWT2
|
UniProt Splice Variant |
|
Entrez Gene |
76890
|
UniGene |
|
RefSeq |
NP_598532
|
MGI ID |
|
MGI Symbol |
Memo1
|
OMIM |
|
CCDS |
CCDS28969
|
HPRD |
|
IMGT |
|
EMBL |
AF363447
AK159560
BC013819
|
GenPept |
AAH13819
AAL34463
BAE35184
|
|
|