InnateDB Protein
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IDBP-197726.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Esyt1
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Protein Name
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extended synaptotagmin-like protein 1
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Synonyms
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Fam62a; Mbc2; vp115;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026427
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InnateDB Gene
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IDBG-197724 (Esyt1)
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Protein Structure
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Function |
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1344426
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InterPro |
IPR000008
C2 domain
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PFAM |
PF00168
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U7R1
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PhosphoSite |
PhosphoSite-Q3U7R1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23943
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UniGene |
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RefSeq |
NP_035973
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MGI ID |
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MGI Symbol |
Esyt1
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OMIM |
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CCDS |
CCDS24280
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HPRD |
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IMGT |
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EMBL |
AF098633
AF098634
AK008224
AK044656
AK152482
AK152554
BC011482
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GenPept |
AAD10189
AAD10190
AAH11482
BAB25542
BAC32020
BAE31254
BAE31308
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