InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv1

Summary

InnateDB Protein

IDBP-198048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv1

Protein Name

transient receptor potential cation channel, subfamily V, member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099585

InnateDB Gene

IDBG-198046 (Trpv1)

Protein Structure

UniProt Annotation

Function

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. {ECO:0000250, ECO:0000269PubMed:15194687, ECO:0000269PubMed:15489017}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004698	calcium-dependent protein kinase C activity
GO:0004888	transmembrane signaling receptor activity
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005231	excitatory extracellular ligand-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008324	cation transmembrane transporter activity
GO:0015276	ligand-gated ion channel activity
GO:0015278	calcium-release channel activity
GO:0017081	chloride channel regulator activity
GO:0042802	identical protein binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001660	fever generation
GO:0001774	microglial cell activation
GO:0002024	diet induced thermogenesis
GO:0002790	peptide secretion
GO:0006468	protein phosphorylation
GO:0006629	lipid metabolic process
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009268	response to pH
GO:0009408	response to heat
GO:0010243	response to organonitrogen compound
GO:0014047	glutamate secretion
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0034220	ion transmembrane transport
GO:0042637	catagen
GO:0043065	positive regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0050954	sensory perception of mechanical stimulus
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0060083	smooth muscle contraction involved in micturition
GO:0060454	positive regulation of gastric acid secretion
GO:0070588	calcium ion transmembrane transport
GO:0071312	cellular response to alkaloid
GO:0071318	cellular response to ATP
GO:0071345	cellular response to cytokine stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071502	cellular response to temperature stimulus
GO:0090212	negative regulation of establishment of blood-brain barrier
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0031226	intrinsic component of plasma membrane
GO:0032591	dendritic spine membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1341787

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415
PR01768

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt