InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epha8

Summary

InnateDB Protein

IDBP-198291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha8

Protein Name

Eph receptor A8

Synonyms

AW047546; Eek; Hek3; mKIAA1459;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030420

InnateDB Gene

IDBG-198289 (Epha8)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. {ECO:0000269PubMed:10498895, ECO:0000269PubMed:11416136, ECO:0000269PubMed:12681484, ECO:0000269PubMed:15782114, ECO:0000269PubMed:17875921, ECO:0000269PubMed:9214628}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.

Disease Associations

Tissue Specificity

Specifically expressed in the central nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006929	substrate-dependent cell migration
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0016322	neuron remodeling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0031175	neuron projection development
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0031901	early endosome membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:109378

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM