InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Traip

Summary

InnateDB Protein

IDBP-198674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traip

Protein Name

TRAF-interacting protein

Synonyms

Trip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040001

InnateDB Gene

IDBG-198670 (Traip)

Protein Structure

UniProt Annotation

Function

May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity (By similarity). Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'- linked polyubiquitination of TNK1 leading to its proteasomal degradation. {ECO:0000250, ECO:0000269PubMed:17544371, ECO:0000269PubMed:22945920}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Occasionally observed at nuclear puncta. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in testis and thymus, and at lower levels in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1096377

InterPro

IPR001841 Zinc finger, RING-type
IPR009053 Prefoldin
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00097

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VIG6

PhosphoSite

PhosphoSite-Q8VIG6

TrEMBL

UniProt Splice Variant

Entrez Gene

22036

UniGene

RefSeq

NP_035764

MGI ID

MGI Symbol

Traip

OMIM

CCDS

CCDS23511

HPRD

IMGT

EMBL

AK012786 AK012948 BC006929 BC017374 U77844

GenPept

AAB52994 AAH06929 AAH17374 BAB28469 BAB28567