InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD9

Summary

InnateDB Protein

IDBP-19869.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD9

Protein Name

frizzled family receptor 9

Synonyms

CD349; FZD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000345785

InnateDB Gene

IDBG-19867 (FZD9)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity
GO:0042813	Wnt-activated receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0007611	learning or memory
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030183	B cell differentiation
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031527	filopodium membrane
GO:0048471	perinuclear region of cytoplasm