InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyr61

Summary

InnateDB Protein

IDBP-198708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyr61

Protein Name

cysteine rich protein 61

Synonyms

AI325051; CCN1; Igfbp10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029846

InnateDB Gene

IDBG-198706 (Cyr61)

Protein Structure

UniProt Annotation

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down- regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008201	heparin binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0002041	intussusceptive angiogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003278	apoptotic process involved in heart morphogenesis
GO:0003281	ventricular septum development
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0010518	positive regulation of phospholipase activity
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0033690	positive regulation of osteoblast proliferation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044319	wound healing, spreading of cells
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060413	atrial septum morphogenesis
GO:0060591	chondroblast differentiation
GO:0060710	chorio-allantoic fusion
GO:0060716	labyrinthine layer blood vessel development
GO:0061036	positive regulation of cartilage development
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0072593	reactive oxygen species metabolic process
GO:2000304	positive regulation of ceramide biosynthetic process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:88613

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt