Version 5.4
Mus musculus Protein: Spire2
Summary
InnateDB Protein IDBP-198895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spire2
Protein Name spire homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000010298
InnateDB Gene IDBG-198893 (Spire2)
Protein Structure
UniProt Annotation
Function Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269PubMed:21620703, ECO:0000269PubMed:21983562}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:21983562}. Cytoplasm, cytosol {ECO:0000269PubMed:21983562}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269PubMed:21983562}; Peripheral membrane protein {ECO:0000269PubMed:21983562}; Cytoplasmic side {ECO:0000269PubMed:21983562}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:21983562}; Peripheral membrane protein {ECO:0000269PubMed:21983562}; Cytoplasmic side {ECO:0000269PubMed:21983562}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
Disease Associations
Tissue Specificity Detected in oocytes. {ECO:0000269PubMed:21620703}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030036 actin cytoskeleton organization
GO:0036089 cleavage furrow formation
GO:0040038 polar body extrusion after meiotic divisions
GO:0046907 intracellular transport
GO:0051295 establishment of meiotic spindle localization
GO:0070649 formin-nucleated actin cable assembly
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0030659 cytoplasmic vesicle membrane
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2446256
InterPro IPR011011 Zinc finger, FYVE/PHD-type
IPR011019 KIND
PFAM
PRINTS
PIRSF
SMART SM00750
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1S6
PhosphoSite PhosphoSite-Q8K1S6
TrEMBL D5MR13
UniProt Splice Variant
Entrez Gene 234857
UniGene Mm.150200
RefSeq NP_758491
MGI ID
MGI Symbol Spire2
OMIM
CCDS CCDS22754
HPRD
IMGT
EMBL AB504792 AB504793 AB504794 AB504795 AB504796 AB504797 AB504798 AB504799 AB504800 AB504801 AJ459115 BC026502 BC049152
GenPept AAH26502 AAH49152 BAJ07134 BAJ07135 BAJ07136 BAJ07137 BAJ07138 BAJ07139 BAJ07140 BAJ07141 BAJ07142 BAJ07143 CAD30509

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca