InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs16

Summary

InnateDB Protein

IDBP-199252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs16

Protein Name

regulator of G-protein signaling 16

Synonyms

Rgs14; Rgsr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027748

InnateDB Gene

IDBG-199250 (Rgs16)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.

Subcellular Localization

Disease Associations

Tissue Specificity

Retinal; also predominantly expressed in the liver and pituitary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity