InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkd3

Summary

InnateDB Protein

IDBP-199326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkd3

Protein Name

protein kinase D3

Synonyms

4930557O20Rik; 5730497N19Rik; Pkcnu; PKD3; Prkcn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003191

InnateDB Gene

IDBG-199324 (Prkd3)

Protein Structure

UniProt Annotation

Function

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1922542

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00169
PF00130
PF06293

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00233
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt