InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amt

Summary

InnateDB Protein

IDBP-199580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amt

Protein Name

aminomethyltransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035230

InnateDB Gene

IDBG-199578 (Amt)

Protein Structure

UniProt Annotation

Function

The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004047	aminomethyltransferase activity
GO:0008483	transaminase activity

Biological Process

GO:0006546	glycine catabolic process
GO:0032259	methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:3646700

InterPro

IPR006222 Glycine cleavage T-protein, N-terminal
IPR006223 Glycine cleavage system T protein
IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA
IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain

PFAM

PF01571
PF08669

PRINTS

PIRSF

PIRSF006487

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CFA2