Version 5.4
Mus musculus Protein: Ints4
Summary
InnateDB Protein IDBP-199758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints4
Protein Name integrator complex subunit 4
Synonyms 2610034N24Rik; AA692684; AW493223;
Species Mus musculus
Ensembl Protein ENSMUSP00000026126
InnateDB Gene IDBG-199756 (Ints4)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID MGI:1917164
InterPro IPR000357 HEAT
IPR016024 Armadillo-type fold
PFAM PF02985
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CIM8
PhosphoSite PhosphoSite-Q8CIM8
TrEMBL
UniProt Splice Variant
Entrez Gene 101861
UniGene Mm.27383
RefSeq NP_081532
MGI ID
MGI Symbol Ints4
OMIM
CCDS CCDS21460
HPRD
IMGT
EMBL AK011676 AK088635 AK163383 BC013710 BC013813
GenPept AAH13710 AAH13813 BAB27773 BAC40468 BAE37328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca