InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamb2

Summary

InnateDB Protein

IDBP-199880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamb2

Protein Name

laminin, beta 2

Synonyms

AW211941; Lamb-2; Lams; npht;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069087

InnateDB Gene

IDBG-199878 (Lamb2)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. {ECO:0000269PubMed:7885444}.Laminin-3 (S-laminin) regulates the formation of motor nerve terminals. {ECO:0000269PubMed:7885444}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Neuromuscular synapse and kidney glomerulus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0007601	visual perception
GO:0014002	astrocyte development
GO:0014044	Schwann cell development
GO:0031175	neuron projection development
GO:0048677	axon extension involved in regeneration
GO:0050808	synapse organization
GO:0060041	retina development in camera-type eye
GO:0072249	metanephric glomerular visceral epithelial cell development
GO:0072274	metanephric glomerular basement membrane development

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005608	laminin-3 complex
GO:0031012	extracellular matrix
GO:0043256	laminin complex
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome