Version 5.4
Mus musculus Protein: Tor1aip1
Summary
InnateDB Protein IDBP-200108.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tor1aip1
Protein Name torsin A interacting protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095134
InnateDB Gene IDBG-200102 (Tor1aip1)
Protein Structure
UniProt Annotation
Function Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269PubMed:20457914}.
Subcellular Localization Nucleus inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the spinal cord and liver (at protein level). {ECO:0000269PubMed:16364897}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0005521 lamin binding
Biological Process
GO:0032781 positive regulation of ATPase activity
GO:0034504 protein localization to nucleus
GO:0071763 nuclear membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3582693
InterPro IPR008662 Lamina-associated polypeptide 1C
PFAM PF05609
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q921T2
PhosphoSite PhosphoSite-Q921T2
TrEMBL E9PWW2
UniProt Splice Variant
Entrez Gene 208263
UniGene Mm.211654
RefSeq NP_001153490
MGI ID
MGI Symbol Tor1aip1
OMIM
CCDS CCDS48402
HPRD
IMGT
EMBL AB251963 AC159964 AK152751 BC010841
GenPept AAH10841 BAE31466 BAE94915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca