InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nphs2

Summary

InnateDB Protein

IDBP-200234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nphs2

Protein Name

nephrosis 2 homolog, podocin (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027896

InnateDB Gene

IDBG-200232 (Nphs2)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007588	excretion
GO:0031532	actin cytoskeleton reorganization
GO:0072249	metanephric glomerular visceral epithelial cell development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0036057	slit diaphragm
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome