InnateDB Protein
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IDBP-200462.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fam20b
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Protein Name
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family with sequence similarity 20, member B
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000083322
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InnateDB Gene
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IDBG-200460 (Fam20b)
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Protein Structure
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Function |
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Little expression detected in the secretory stage enamel. Weak to moderate expression is observed in the gingivae and odontoblasts. Strong expression in maturation stage ameloblasts. {ECO:0000269PubMed:21549343}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443990
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InterPro |
IPR009581
Domain of unknown function DUF1193
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PFAM |
PF06702
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VCS3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
215015
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UniGene |
Mm.229107
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RefSeq |
NP_663388
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MGI ID |
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MGI Symbol |
Fam20b
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OMIM |
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CCDS |
CCDS15395
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HPRD |
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IMGT |
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EMBL |
AK049705
AK129154
AK132149
BC019381
BC023737
BC024412
BC031473
CH466520
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GenPept |
AAH19381
AAH23737
AAH24412
AAH31473
BAC33883
BAC97964
BAE20998
EDL39377
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