InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinh1

Summary

InnateDB Protein

IDBP-200627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinh1

Protein Name

serine (or cysteine) peptidase inhibitor, clade H, member 1

Synonyms

BERF-1; Cbp1; Cbp2; gp46; Hsp47; J6; Serpinh2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091706

InnateDB Gene

IDBG-200623 (Serpinh1)

Protein Structure

UniProt Annotation

Function

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Subcellular Localization

Endoplasmic reticulum lumen.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0003433	chondrocyte development involved in endochondral bone morphogenesis
GO:0006950	response to stress
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030199	collagen fibril organization
GO:0032964	collagen biosynthetic process
GO:0051604	protein maturation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment