Version 5.4
Mus musculus Protein: Gdpd5
Summary
InnateDB Protein IDBP-200659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdpd5
Protein Name glycerophosphodiester phosphodiesterase domain containing 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036175
InnateDB Gene IDBG-200657 (Gdpd5)
Protein Structure
UniProt Annotation
Function Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. {ECO:0000269PubMed:17275818, ECO:0000269PubMed:18667693}.
Subcellular Localization Endomembrane system {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In a punctate perinuclear pattern.
Disease Associations
Tissue Specificity Detected in brain, lung, heart, kidney and testis. {ECO:0000269PubMed:15276213}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006629 lipid metabolic process
GO:0021522 spinal cord motor neuron differentiation
GO:0021895 cerebral cortex neuron differentiation
GO:0031175 neuron projection development
GO:0045666 positive regulation of neuron differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0048505 regulation of timing of cell differentiation
Cellular Component
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030426 growth cone
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2686926
InterPro IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q640M6
PhosphoSite PhosphoSite-Q640M6
TrEMBL
UniProt Splice Variant
Entrez Gene 233552
UniGene Mm.286317
RefSeq NP_958740
MGI ID
MGI Symbol Gdpd5
OMIM
CCDS CCDS21481
HPRD
IMGT
EMBL AK141189 AK154771 BC024955 BC026428 BC082585
GenPept AAH24955 AAH26428 AAH82585 BAE24577 BAE32819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca