InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRP72

Summary

InnateDB Protein

IDBP-20093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRP72

Protein Name

signal recognition particle 72kDa

Synonyms

BMFF; BMFS1; HEL103;

Species

Homo sapiens

Ensembl Protein

ENSP00000342181

InnateDB Gene

IDBG-20091 (SRP72)

Protein Structure

UniProt Annotation

Function

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22541560}. Endoplasmic reticulum {ECO:0000269PubMed:22541560}.

Disease Associations

Bone marrow failure syndrome 1 (BMFS1) [MIM:614675]: An autosomal dominant disease characterized by aplastic anemia and myelodysplasia resulting from bone marrow failure. Aplastic anemia is a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Myelodysplasia is a clonal hematopoietic stem cell disorder in which immature cells in the bone marrow become malformed and dysfunctional. {ECO:0000269PubMed:22541560}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005047	signal recognition particle binding
GO:0005515	protein binding
GO:0008312	7S RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0042493	response to drug
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005786	signal recognition particle, endoplasmic reticulum targeting
GO:0005829	cytosol
GO:0048500	signal recognition particle

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013699 Signal recognition particle, SRP72 subunit, RNA-binding
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF08492
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O76094