InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcne3

Summary

InnateDB Protein

IDBP-201059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcne3

Protein Name

potassium voltage-gated channel, Isk-related subfamily, gene 3

Synonyms

2210017H05Rik; MiRP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039353

InnateDB Gene

IDBG-201057 (Kcne3)

Protein Structure

UniProt Annotation

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0043266	regulation of potassium ion transport
GO:0071805	potassium ion transmembrane transport