InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epcam

Summary

InnateDB Protein

IDBP-201439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epcam

Protein Name

epithelial cell adhesion molecule

Synonyms

CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1; GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061935

InnateDB Gene

IDBG-201437 (Epcam)

Protein Structure

UniProt Annotation

Function

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Lateral cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001657	ureteric bud development
GO:0008284	positive regulation of cell proliferation
GO:0023019	signal transduction involved in regulation of gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome