InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P2ry2

Summary

InnateDB Protein

IDBP-201763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2ry2

Protein Name

purinergic receptor P2Y, G-protein coupled 2

Synonyms

P2U1; P2Y2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036765

InnateDB Gene

IDBG-201761 (P2ry2)

Protein Structure

UniProt Annotation

Function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Spleen, testis, kidney, liver, lung, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042312	regulation of vasodilation
GO:0070257	positive regulation of mucus secretion