InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fmo3

Summary

InnateDB Protein

IDBP-202039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fmo3

Protein Name

flavin containing monooxygenase 3

Synonyms

AW111792;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028010

InnateDB Gene

IDBG-202037 (Fmo3)

Protein Structure

UniProt Annotation

Function

Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide. {ECO:0000269PubMed:23177478}.

Subcellular Localization

Microsome membrane. Endoplasmic reticulum membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0016597	amino acid binding
GO:0034899	trimethylamine monooxygenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0017144	drug metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1100496

InterPro

IPR000960 Flavin monooxygenase FMO
IPR002253 Flavin monooxygenase (FMO) 1
IPR002254 Flavin monooxygenase (FMO) 2
IPR002255 Flavin monooxygenase (FMO) 3
IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
IPR020946 Flavin monooxygenase-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00743
PF07992

PRINTS

PR00370
PR01121
PR01122
PR01123

PIRSF

PIRSF000332

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt