InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eral1

Summary

InnateDB Protein

IDBP-202164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eral1

Protein Name

Era (G-protein)-like 1 (E. coli)

Synonyms

2610524P08Rik; 9130407C09Rik; AU019798; Era; M-ERA; MERA-S; MERA-W;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021183

InnateDB Gene

IDBG-202162 (Eral1)

Protein Structure

UniProt Annotation

Function

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes on the matrix side on the mitochondrial inner membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0019843	rRNA binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0007264	small GTPase mediated signal transduction
GO:0015684	ferrous iron transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1889295

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001401 Dynamin, GTPase domain
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR006703 AIG1
IPR009019 K homology domain, prokaryotic type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00350
PF01926
PF04548
PF02421
PF08477

PRINTS

PR00315
PR00326

PIRSF

SMART

SM00053

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt