InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ell3

Summary

InnateDB Protein

IDBP-202328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ell3

Protein Name

elongation factor RNA polymerase II-like 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028679

InnateDB Gene

IDBG-202326 (Ell3)

Protein Structure

UniProt Annotation

Function

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P- TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). {ECO:0000269PubMed:22768269, ECO:0000269PubMed:23273992}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23273992}.

Disease Associations

Tissue Specificity

Actively expressed in embryonic stem cells (ES cells), while it is weakly expressed in differentiated cells. {ECO:0000269PubMed:22768269}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035326	enhancer binding

Biological Process

GO:0006354	DNA-dependent transcription, elongation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation
GO:0050769	positive regulation of neurogenesis
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0008023	transcription elongation factor complex

Protein Structure and Domains

PDB ID

MGI:2673679

InterPro

IPR010844 Occludin/RNA polymerase II elongation factor, ELL domain
IPR019464 RNA polymerase II elongation factor ELL

PFAM

PF07303
PF10390

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80VR2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

269344

UniGene

Mm.488519

RefSeq

MGI ID

MGI Symbol

Ell3

OMIM

CCDS

CCDS16644

HPRD

IMGT

EMBL

AL845466 BC045151

GenPept

AAH45151 CAM24232