Version 5.4
Mus musculus Protein: Il18bp
Summary
InnateDB Protein IDBP-202397.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il18bp
Protein Name interleukin 18 binding protein
Synonyms Igifbp; IL-18BP; MC54L;
Species Mus musculus
Ensembl Protein ENSMUSP00000091685
InnateDB Gene IDBG-202395 (Il18bp)
Protein Structure
UniProt Annotation
Function Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042007 interleukin-18 binding
Biological Process
GO:0032496 response to lipopolysaccharide
GO:0042088 T-helper 1 type immune response
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1333800
InterPro IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0M9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16068
UniGene
RefSeq NP_034661
MGI ID
MGI Symbol Il18bp
OMIM
CCDS CCDS21522
HPRD
IMGT
EMBL AB019505 AF110802 AF110803 AF122907 AK003370 AK008452 AK009721 AK009877 BC018332 CH466531 CT010164 CT010334
GenPept AAD17193 AAD17194 AAD41052 AAH18332 BAA76375 BAB22744 BAB25677 BAB26462 BAB26558 CAJ18372 CAJ18542 EDL16557 EDL16558 EDL16559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca