Version 5.4
Mus musculus Protein: Dpt
Summary
InnateDB Protein IDBP-202535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpt
Protein Name dermatopontin
Synonyms 1810032B19Rik; 5033416F05Rik; EQ-1; Eq1;
Species Mus musculus
Ensembl Protein ENSMUSP00000027861
InnateDB Gene IDBG-202533 (Dpt)
Protein Structure
UniProt Annotation
Function Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. {ECO:0000250, ECO:0000269PubMed:12230512, ECO:0000269PubMed:14980498}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0030199 collagen fibril organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1928392
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZZ6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56429
UniGene Mm.28935
RefSeq NP_062733
MGI ID
MGI Symbol Dpt
OMIM
CCDS CCDS15437
HPRD
IMGT
EMBL AF143374 AK019890 BC046420
GenPept AAD54221 AAH46420 BAB31905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca