Version 5.4
Mus musculus Protein: Dcaf6
Summary
InnateDB Protein IDBP-202635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcaf6
Protein Name DDB1 and CUL4 associated factor 6
Synonyms 1200006M05Rik; Iqwd1; PC326;
Species Mus musculus
Ensembl Protein ENSMUSP00000027856
InnateDB Gene IDBG-202633 (Dcaf6)
Protein Structure
UniProt Annotation
Function Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0016567 protein ubiquitination
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1921356
InterPro IPR000048 IQ motif, EF-hand binding site
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00612
PF00400
PRINTS
PIRSF
SMART SM00015
SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DC22
PhosphoSite PhosphoSite-Q9DC22
TrEMBL
UniProt Splice Variant
Entrez Gene 74106
UniGene Mm.393093
RefSeq NP_083035
MGI ID
MGI Symbol Dcaf6
OMIM
CCDS CCDS48424
HPRD
IMGT
EMBL AK004618 AK077238
GenPept BAB23414 BAC36701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca