InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mpc2

Summary

InnateDB Protein

IDBP-202660.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpc2

Protein Name

brain protein 44

Synonyms

0610006C01Rik; 2010002I07Rik; 2610205H19Rik; AA108335; Brp44; ESTM43;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027853

InnateDB Gene

IDBG-202658 (Mpc2)

Protein Structure

UniProt Annotation

Function

Mediates the uptake of pyruvate into mitochondria. {ECO:0000269PubMed:22628554}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:22628554}; Multi-pass membrane protein {ECO:0000269PubMed:22628554}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0050833	pyruvate transmembrane transporter activity

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006850	mitochondrial pyruvate transport
GO:1901475	pyruvate transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1917706

InterPro

IPR005336 Mitochondrial pyruvate carrier

PFAM

PF03650

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D023

PhosphoSite

PhosphoSite-Q9D023

TrEMBL

UniProt Splice Variant

Entrez Gene

70456

UniGene

Mm.195625

RefSeq

NP_081706

MGI ID

MGI Symbol

Mpc2

OMIM

CCDS

CCDS15442

HPRD

IMGT

EMBL

AK002233 AK011889 AK151522 BC018324

GenPept

AAH18324 BAB27898 BAC24983 BAE30471