Version 5.4
Mus musculus Protein: Trim69
Summary
InnateDB Protein IDBP-202760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim69
Protein Name tripartite motif-containing 69
Synonyms 4921519C19Rik; Rnf36; Trif; Trimless;
Species Mus musculus
Ensembl Protein ENSMUSP00000047627
InnateDB Gene IDBG-202758 (Trim69)
Protein Structure
UniProt Annotation
Function May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. {ECO:0000269PubMed:12837286}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle.
Disease Associations
Tissue Specificity Expressed in spermatid. {ECO:0000269PubMed:11578878}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1918178
InterPro IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00622
PF13765
PF00097
PRINTS PR01407
PIRSF
SMART SM00184
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80X56
PhosphoSite PhosphoSite-Q80X56
TrEMBL
UniProt Splice Variant
Entrez Gene 70928
UniGene Mm.379188
RefSeq NP_536771
MGI ID
MGI Symbol Trim69
OMIM
CCDS CCDS16655
HPRD
IMGT
EMBL AF334958 AL845457 BC050815
GenPept AAH50815 AAL41031 CAM19390 CAM21784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca