InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gatm

Summary

InnateDB Protein

IDBP-203089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gatm

Protein Name

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Synonyms

1810003P21Rik; AI314789; AT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028624

InnateDB Gene

IDBG-203087 (Gatm)

Protein Structure

UniProt Annotation

Function

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. {ECO:0000269PubMed:12671064}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney, brain, gonads, uterus, and embryonic head, chest and abdomen. Maternally expressed in the placenta and yolk sac of embryos. {ECO:0000269PubMed:12671064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015067	amidinotransferase activity
GO:0015068	glycine amidinotransferase activity
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0006601	creatine biosynthetic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009790	embryo development
GO:0010033	response to organic substance
GO:0042246	tissue regeneration
GO:0043434	response to peptide hormone
GO:0046689	response to mercury ion