InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nos2

Summary

InnateDB Protein

IDBP-203205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nos2

Protein Name

nitric oxide synthase 2, inducible

Synonyms

i-NOS; iNOS; Nos-2; NOS-II; Nos2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018610

InnateDB Gene

IDBG-203203 (Nos2)

Protein Structure

UniProt Annotation

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. {ECO:0000269PubMed:16373578}.

Subcellular Localization

Disease Associations

Tissue Specificity

Macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	15 [view]
Protein-DNA	34 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	159 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005102	receptor binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0034617	tetrahydrobiopterin binding
GO:0034618	arginine binding
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001666	response to hypoxia
GO:0006527	arginine catabolic process
GO:0006801	superoxide metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006954	inflammatory response
GO:0007263	nitric oxide mediated signal transduction
GO:0007623	circadian rhythm
GO:0010629	negative regulation of gene expression
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0032496	response to lipopolysaccharide
GO:0042127	regulation of cell proliferation
GO:0042177	negative regulation of protein catabolic process
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0050796	regulation of insulin secretion
GO:0051712	positive regulation of killing of cells of other organism
GO:0055114	oxidation-reduction process
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0030863	cortical cytoskeleton
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:97361

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, oxygenase domain
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt