InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubp1

Summary

InnateDB Protein

IDBP-203222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubp1

Protein Name

upstream binding protein 1

Synonyms

Cp2b; LBP-1a; LBP-1b; NF2d9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009885

InnateDB Gene

IDBG-203220 (Ubp1)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha- globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in erythroid cells. {ECO:0000269PubMed:15988015, ECO:0000269PubMed:7623810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:104889

InterPro

IPR007604 CP2 transcription factor
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF04516

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q811S7

PhosphoSite

PhosphoSite-Q811S7

TrEMBL

UniProt Splice Variant

Entrez Gene

22221

UniGene

Mm.396708

RefSeq

NP_038727

MGI ID

MGI Symbol

Ubp1

OMIM

CCDS

CCDS40789

HPRD

IMGT

EMBL

AK079815 AK140942 AK143282 AY182062 BC139828 U20086

GenPept

AAC52244 AAI39829 AAO24130 BAC37754 BAE24526 BAE25332