Version 5.4
Mus musculus Protein: Crtap
Summary
InnateDB Protein IDBP-203417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crtap
Protein Name cartilage associated protein
Synonyms 5730529N23Rik; CASP; Leprel3;
Species Mus musculus
Ensembl Protein ENSMUSP00000081941
InnateDB Gene IDBG-203415 (Crtap)
Protein Structure
UniProt Annotation
Function Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. {ECO:0000269PubMed:17055431}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations Note=Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production.
Tissue Specificity Found in articular chondrocytes. Expressed in a variety of tissues. {ECO:0000269PubMed:17055431}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0032403 protein complex binding
Biological Process
GO:0007283 spermatogenesis
GO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline
GO:0050821 protein stabilization
GO:0061077 chaperone-mediated protein folding
GO:1901874 negative regulation of post-translational protein modification
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0032991 macromolecular complex
Protein Structure and Domains
PDB ID MGI:1891221
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CYD3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56693
UniGene Mm.20904
RefSeq NP_064306
MGI ID
MGI Symbol Crtap
OMIM
CCDS CCDS23592
HPRD
IMGT
EMBL AJ006469 AK017797 AK047506 BC049890
GenPept AAH49890 BAB30938 BAC33076 CAA07053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca