InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wbscr22

Summary

InnateDB Protein

IDBP-203439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wbscr22

Protein Name

Williams Beuren syndrome chromosome region 22

Synonyms

1110003N24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083146

InnateDB Gene

IDBG-203433 (Wbscr22)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus- specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized diffusely throughout the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364	rRNA processing
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0032259	methylation

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1913388

InterPro

IPR013216 Methyltransferase type 11
IPR022238 Uncharacterised protein family, methyltransferase, Williams-Beuren syndrome
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08241
PF12589

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CY21

PhosphoSite