InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs5

Summary

InnateDB Protein

IDBP-203511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs5

Protein Name

regulator of G-protein signaling 5

Synonyms

1110070A02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027997

InnateDB Gene

IDBG-203509 (Rgs5)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway