InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl24

Summary

InnateDB Protein

IDBP-203949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl24

Protein Name

chemokine (C-C motif) ligand 24

Synonyms

CKb-6; MPIF-2; Scya24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004936

InnateDB Gene

IDBG-203945 (Ccl24)

Protein Structure

UniProt Annotation

Function

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis. {ECO:0000269PubMed:11067944}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008009	chemokine activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0048245	eosinophil chemotaxis
GO:0050729	positive regulation of inflammatory response
GO:2000418	positive regulation of eosinophil migration