InnateDB Protein
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IDBP-204211.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Draxin
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Protein Name
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RIKEN cDNA 2610109H07 gene
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Synonyms
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2610109H07Rik; neucrin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030862
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InnateDB Gene
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IDBG-204209 (Draxin)
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Protein Structure
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Function |
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255HAMAP- Rule:MF_03060, ECO:0000269PubMed:19857465}.
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Subcellular Localization |
Secreted {ECO:0000255HAMAP-Rule:MF_03060}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge. {ECO:0000269PubMed:19150847, ECO:0000269PubMed:19857465}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917683
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PAL1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
70433
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UniGene |
Mm.275288
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RefSeq |
NP_081702
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MGI ID |
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MGI Symbol |
Draxin
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OMIM |
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CCDS |
CCDS18931
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HPRD |
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IMGT |
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EMBL |
AB301918
AK086198
AL606929
BC060239
CU207376
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GenPept |
AAH60239
BAC39628
BAG80560
CAM14900
CAQ51921
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