InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctdspl

Summary

InnateDB Protein

IDBP-204279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctdspl

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

Synonyms

2810418J22Rik; AI426263; HYA22; SCP3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072852

InnateDB Gene

IDBG-204277 (Ctdspl)

Protein Structure

UniProt Annotation

Function

Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0046872	metal ion binding