Version 5.4
Mus musculus Protein: Ccl12
Summary
InnateDB Protein IDBP-204541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccl12
Protein Name chemokine (C-C motif) ligand 12
Synonyms MCP-5; Scya12;
Species Mus musculus
Ensembl Protein ENSMUSP00000000194
InnateDB Gene IDBG-204539 (Ccl12)
Protein Structure
UniProt Annotation
Function Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0031727 CCR2 chemokine receptor binding
Biological Process
GO:0001525 angiogenesis
GO:0002548 monocyte chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:108224
InterPro IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62401
PhosphoSite PhosphoSite-
TrEMBL Q545B5
UniProt Splice Variant
Entrez Gene 20293
UniGene Mm.867
RefSeq NP_035461
MGI ID
MGI Symbol Ccl12
OMIM
CCDS CCDS36247
HPRD
IMGT
EMBL AF065934 AF065935 AF065936 AF065937 AF065938 AK012356 BC027520 DS033261 DS033265 U50712 U66670
GenPept AAB49424 AAB50053 AAF15384 AAF15385 AAF15386 AAF15387 AAF15388 AAH27520 BAB28185 EDL01207 EDL01219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca