InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lig3

Summary

InnateDB Protein

IDBP-204690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lig3

Protein Name

ligase III, DNA, ATP-dependent

Synonyms

D11Wsu78e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021039

InnateDB Gene

IDBG-204684 (Lig3)

Protein Structure

UniProt Annotation

Function

The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

The alpha isoform is expressed in all tissues, while the beta isoform is expressed only in the testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003910	DNA ligase (ATP) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding

Biological Process

GO:0006266	DNA ligation
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007049	cell cycle
GO:0043504	mitochondrial DNA repair
GO:0045910	negative regulation of DNA recombination
GO:0051103	DNA ligation involved in DNA repair
GO:0051301	cell division
GO:0071897	DNA biosynthetic process

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

MGI:109152

InterPro

IPR000977 DNA ligase, ATP-dependent
IPR001357 BRCT domain
IPR001510 Zinc finger, PARP-type
IPR012308 DNA ligase, ATP-dependent, N-terminal
IPR012309 DNA ligase, ATP-dependent, C-terminal
IPR012310 DNA ligase, ATP-dependent, central
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF00533
PF12738
PF00645
PF04675
PF04679
PF01068

PRINTS

PIRSF

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97386