Version 5.4
Mus musculus Protein: Cd244
Summary
InnateDB Protein IDBP-204696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd244
Protein Name CD244 natural killer cell receptor 2B4
Synonyms 2B4; C9.1; F730046O15Rik; Ly90; NAIL; NKR2B4; Nmrk; SLAMF4;
Species Mus musculus
Ensembl Protein ENSMUSP00000004829
InnateDB Gene IDBG-204694 (Cd244)
Protein Structure
UniProt Annotation
Function Modulates other receptor-ligand interactions to enhance leukocyte activation (By similarity). CD244/2B4 is the only heterophilic receptor of SLAM family. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:109294
InterPro IPR013106 Immunoglobulin V-set domain
IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain
PFAM PF07686
PF11465
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07763
PhosphoSite PhosphoSite-Q07763
TrEMBL
UniProt Splice Variant
Entrez Gene 18106
UniGene Mm.2299
RefSeq NP_061199
MGI ID 2PTU
MGI Symbol Cd244
OMIM
CCDS CCDS35778
HPRD
IMGT
EMBL AF082803 AF234831 AK137505 L19057
GenPept AAA16353 AAC34859 AAF91290 BAE23386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca