InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim56

Summary

InnateDB Protein

IDBP-204817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim56

Protein Name

tripartite motif-containing 56

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058109

InnateDB Gene

IDBG-204815 (Trim56)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of type I interferon IFN- beta following detection of pathogen- and host-derived double- stranded DNA. {ECO:0000269PubMed:21074459}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21074459}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0032608	interferon-beta production
GO:0034340	response to type I interferon
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0070534	protein K63-linked ubiquitination
GO:1902187	negative regulation of viral release from host cell