Version 5.4
Mus musculus Protein: Gpat2
Summary
InnateDB Protein IDBP-204837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpat2
Protein Name glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000049619
InnateDB Gene IDBG-204835 (Gpat2)
Protein Structure
UniProt Annotation
Function Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. {ECO:0000269PubMed:17013544, ECO:0000269PubMed:17689486}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:17013544, ECO:0000269PubMed:17689486, ECO:0000269PubMed:22285183}; Multi-pass membrane protein {ECO:0000269PubMed:17013544, ECO:0000269PubMed:17689486, ECO:0000269PubMed:22285183}.
Disease Associations
Tissue Specificity Highly exprresed in the testis. Expressed at lower levels in the heart, liver, kidney, spleen and adipose cells. {ECO:0000269PubMed:17013544, ECO:0000269PubMed:17689486}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2684962
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14DK4
PhosphoSite PhosphoSite-Q14DK4
TrEMBL Q0KK35
UniProt Splice Variant
Entrez Gene 215456
UniGene Mm.440454
RefSeq NP_001074558
MGI ID
MGI Symbol Gpat2
OMIM
CCDS CCDS38232
HPRD
IMGT
EMBL AB257502 AB259570 AB259571 AK040991 AK131154 AL731831 AL731836 BC113165 BC113776
GenPept AAI13166 AAI13777 BAC30772 BAD21404 BAF03614 BAF03615 BAF03616 CAM13442 CAM13878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca