InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srrt

Summary

InnateDB Protein

IDBP-204893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srrt

Protein Name

serrate RNA effector molecule homolog (Arabidopsis)

Synonyms

2810019G02Rik; Ars2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043123

InnateDB Gene

IDBG-204891 (Srrt)

Protein Structure

UniProt Annotation

Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. {ECO:0000269PubMed:19632182, ECO:0000269PubMed:22198669}.

Subcellular Localization

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.

Disease Associations

Tissue Specificity

Widely expressed, with a preference for proliferating cells. Highly expressed in hematopoietic tissues and reduced or absent expression in parenchymal organs like liver and kidney. In the brain, expressed in the subventricular zone by niche astrocytes, ependymal cells and neural stem cells. In this cerebral context, expressed in slowly dividing cells. {ECO:0000269PubMed:18086880, ECO:0000269PubMed:19632182, ECO:0000269PubMed:22198669}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0031053	primary miRNA processing
GO:0097150	neuronal stem cell maintenance