InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif1b

Summary

InnateDB Protein

IDBP-204970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif1b

Protein Name

kinesin family member 1B

Synonyms

A530096N05Rik; AI448212; AI506502; D4Mil1e; KIF1Bp130; KIF1Bp204;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056754

InnateDB Gene

IDBG-204966 (Kif1b)

Protein Structure

UniProt Annotation

Function

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility.

Subcellular Localization

Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Mitochondrion {ECO:0000250}. Note=Colocalizes with synaptophysin at synaptic cytoplasmic transport vesicles in the neurites of hippocampal neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed almost exclusively in adult brain tissue (mainly in the cerebellum and cerebrum) within a single type of neuronal cell.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0007270	neuron-neuron synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0008089	anterograde axon cargo transport
GO:0008152	metabolic process
GO:0009790	embryo development
GO:0030705	cytoskeleton-dependent intracellular transport
GO:0047497	mitochondrion transport along microtubule

Cellular Component

GO:0005739	mitochondrion
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:108426

InterPro

IPR000253 Forkhead-associated (FHA) domain
IPR001752 Kinesin, motor domain
IPR001849 Pleckstrin homology domain
IPR008984 SMAD/FHA domain
IPR022140 Kinesin protein 1B
IPR022164 Kinesin-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00498
PF00225
PF00169
PF12423
PF12473

PRINTS

PR00380

PIRSF

SMART

SM00240
SM00129
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt