InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpp1

Summary

InnateDB Protein

IDBP-204991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpp1

Protein Name

tripeptidyl peptidase I

Synonyms

Cln2; TPP-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033184

InnateDB Gene

IDBG-204989 (Tpp1)

Protein Structure

UniProt Annotation

Function

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0008240	tripeptidyl-peptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007040	lysosome organization
GO:0007399	nervous system development
GO:0030855	epithelial cell differentiation
GO:0043171	peptide catabolic process
GO:0045453	bone resorption
GO:0050885	neuromuscular process controlling balance