InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube4b

Summary

InnateDB Protein

IDBP-205099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube4b

Protein Name

ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)

Synonyms

4930551I19Rik; 4933406G05Rik; AU014668; D4Bwg0973e; mKIAA0684; UFD2; UFD2a; Ufd2p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099501

InnateDB Gene

IDBG-205097 (Ube4b)

Protein Structure

UniProt Annotation

Function

Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. {ECO:0000250UniProtKB:O95155}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11770485, ECO:0000269PubMed:12504083}.

Disease Associations

Tissue Specificity

Expressed predominantly in neuronal tissues. {ECO:0000269PubMed:12504083}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0019899	enzyme binding
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process