InnateDB Protein
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IDBP-20521.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CELF6
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Protein Name
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CUGBP, Elav-like family member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000287202
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InnateDB Gene
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IDBG-20517 (CELF6)
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Protein Structure
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Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. {ECO:0000269PubMed:14761971}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney. {ECO:0000269PubMed:14761971}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q96J87
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PhosphoSite |
PhosphoSite-Q96J87
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TrEMBL |
B3KWE6
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UniProt Splice Variant |
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Entrez Gene |
60677
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UniGene |
Hs.348342
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RefSeq |
NP_443072
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HUGO |
HGNC:14059
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OMIM |
612681
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CCDS |
CCDS10242
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HPRD |
10691
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IMGT |
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EMBL |
AC009690
AF401233
AF425606
AK124858
AK131098
AK294382
AK296004
BC030835
BC033838
CH471082
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GenPept |
AAH30835
AAH33838
AAK95615
AAL34513
BAC85148
BAG54108
BAG57639
BAG58778
EAW77900
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